This protocol was developed for practitioners using Fullscript in Canada and the templates cannot be applied to accounts operating outside of Canada


2 capsules two times daily. Safe to use long term.

Osteoporosis bone health benefits: BoneSure contains a combination of plant-based minerals (from marine algae Lithothamnion corallioides), vitamins (C, D, K), boron, and trace elements to provide full-spectrum remineralization and bone health. It works to improve bone structure and function through increasing bone mineral density, bone strength, and healthy bone formation. (1)(2)(3)(4) When combined with a healthy diet and physical activity, it can reduce the risk of developing osteoporosis (5)(6)(11)(12) and improve bone health in peri-menopausal and menopausal women. (7)(8)(9)(10)(13)

Key features: Increase bone mineralization and bone mineral density, reduce risk of developing osteoporosis, improve bone health in peri-menopausal and menopausal women, plant-sourced multi-minerals, contains 76 naturally occurring trace minerals, high absorption, and bioavailability.

MK7 with Vitamin D3

1 drop once daily. Safe to use long term.

Osteoporosis bone health benefits: MK7 with Vitamin D3 is a combination of vitamin K2 (MK7, menaquinone 7) and vitamin D3 to maintain bone health (3)(4)(10)(13) and improve calcium absorption and binding into the bone matrix. Vitamin D is specifically required for absorption and utilization of phosphorus and calcium, two important components of bones. When vitamin D3 is combined with a healthy diet and physical activity, it can reduce the risk of developing osteoporosis. (11)(12)

Key features: Maintain healthy bones, improve calcium and phosphorus absorption for bone health, reduce the risk of developing osteoporosis.

Basictab or Pleo Alkala N Powder

2 tablets (Basictab) or ½ scoop (Pleo Alkala) twice daily. Take with warm water on an empty stomach. Use for three to six months.

Osteoporosis bone health benefits: Osteoporosis is a condition where there is an impaired structural metabolism of the inorganic and organic bone mass. According to European Biological Medicine, metabolic acidosis (over-acidification) of the tissues causes bone cell dysfunction and reduces bone mineral density. (14) The bones serve as the mineral reservoirs in the body, providing a protective function to maintain normal systemic pH levels. (14) When over-acidification occurs, calcium and other minerals from drawn from the bones and muscles to buffer the excess of acid (hydrogen ions), contributing to calcium loss from the bones. (15)

Alkaline therapy with NaHCO3 (sodium bicarbonate) supplementation increases serum bicarbonate levels in the blood. (16) Recommendations to reverse metabolic acidosis and restore normal pH levels include alkaline therapy, a diet high in alkaline foods, and a reduced protein diet. (17)(18) These recommendations are beneficial in addressing the root cause and the treatment of osteoporosis. (19)

Key features: Rebalance acid-base and proper tissue pH levels, decrease inflammation, support bone health.


The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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  1. Gorman D.M.O., Tierney C.M., Brennan O., Brien F.J.O. The Marine-derived, Multi-mineral formula, Aquamin, Enhances Mineralisation of Osteoblast Cells In Vitro. Phyther. Res. 2012;380:375–380.
  2. Aslam M.N., Kreider J.M., Paruchuri T., et al. A Mineral-Rich Extract from the Red Marine Algae Lithothamnion calcareum Preserves Bone Structure and Function in Female Mice on a Western-Style Diet. Calcif. Tissue Int. 2010;86:313–324. 
  3. Palacios C. The Role of Nutrients in Bone Health, from A to Z. Crit. Rev. Food Sci. Nutr. 2006;46:621–628.
  4. Widaa A., Brennan O., Gorman D.M.O., Brien F.J.O. The Osteogenic Potential of the Marine-Derived Multi-Mineral Formula Aquamin Is Enhanced by the Presence of Vitamin D. Phyther. Res. 2014;684:678–684.
  5. Brennan O, et al. A Natural, Calcium-Rich Marine Multi-Mineral Complex Preserves Bone Structure, Composition and Strength in an Ovariectomised Rat Model of Osteoporosis. Calcified Tissue Int. 2017;101:445–455.
  6. Gorman D.M.O., Tierney C.M., Brennan O., Brien F.J.O. The Marine-derived, Multi-mineral formula, Aquamin, Enhances Mineralisation of Osteoblast Cells In Vitro. Phyther. Res. 2012;380:375–380. 
  7. Zenk J.L., Frestedt J.L., Kuskowski M.A. Effect of Calcium Derived from Lithothamnion sp. on Markers of Calcium Metabolism in Premenopausal Women. J. Med. Food. 2018;21:154–158.
  8. Shea, K.L., Barry, D.W., Sherk, V.D., et al. Calcium Supplementation and PTH Response to Vigorous Walking in Postmenopausal Women. Med Sci Sports Exerc. 2014; 46(10): 2007–2013.
  9. Slevin, M.M., Allsopp, P.J., Magee, P.J, et al. Supplementation with Calcium and Short-Chain Fructo-Oligosaccharides Affects Markers of Bone Turnover but Not Bone Mineral Density in Postmenopausal Women. J Nutr. 2014;144(3):297-304.
  10. Knapen, M.H.J, Drummen, N.E., Smit, E., Vermeer, C., Theuwissen, E. Three-year Low-dose Menaquinone-7 Supplementation Helps Decrease Bone Loss in Healthy Postmenopausal Women. Osteoporos Int. 2013;24(9):2499-507.
  11. Aspray, T.J., Hill, T.R. Osteoporosis and the Ageing Skeleton. Subcell Biochem. 2019;91:453-476.
  12. Chen, L., Hou, P., Chen, K. Nutritional Support and Physical Modalities for People with Osteoporosis: Current Opinion. Nutrients. 2019 Nov 20;11(12):2848.
  13. Huang, Z-B, Wan, S-L, Lu, Y-J, et al. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015 Mar;26(3):1175-86.
  14. Domrongkitchaiporn S., Pongskul C., et al. Bone histology and bone mineral density after correction of acidosis in distal renal tubular acidosis. Kidney Int. 2002;62:2160–2166.
  15. Krieger N.S., Frick K.K., Bushinsky D.A. Mechanism of acid-induced bone resorption. Curr. Opin. Nephrol. Hypertens. 2004;13:423–436.
  16. Abramowitz, M.K., Melamed, M.L., Bauer, C., Raff, A.C., Hostetter, T.H. Effects of Oral Sodium Bicarbonate in Patients with CKD. Clin J Am Soc Nephrol. 2013 May;8(5):714-20.
  17. Siener., R. Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease. Nutrients. 2018 20;10(4):512.
  18. Angeloco, L,R,N, de Souza, G.C.A, Romao, E, A., Chiarello, P.G. Alkaline Diet and Metabolic Acidosis: Practical Approaches to the Nutritional Management of Chronic Kidney Disease. J Ren Nutr. 2018 May;28(3):215-220.
  19. Frassetto, L., Banerjee, T., Powe, N., Sebastian, A. Balance, Dietary Acid Load, and Bone Effects—A Controversial Subject. Nutrients. 2018 Apr; 10(4): 517.