Developed in collaboration with Jennifer McManus, RD, LDN, CDCES 


The Pendulum team has created this protocol in collaboration with practitioners to assist healthcare partners during the creation of individualized patient treatment plans. When using this protocol, you should understand and accept that the recommendations in the protocol are for educational guidance and need to be adapted to meet individual patient needs. This may not be appropriate for every patient. 

This protocol is not a substitute for medical advice or intended to diagnose or treat any medical condition. 


A growing body of evidence suggests that specific, naturally occurring gut bacteria, particularly Akkermansia muciniphila and butyrate-producing microbes, are under-represented in the intestinal tracts. The functions of these microbes, specifically maintenance of gut barrier integrity and butyrate production, are important to already healthy glucose and insulin levels. (1

The short-chain fatty acid, butyrate, is shown to be essential in glucose management by binding to receptors in the gut mucosa and stimulating the release of glucagon-like peptide-1 (GLP-1). (1

In addition to supporting healthy glucose levels, GLP-1 promotes satiety and supports cardiovascular and general metabolic health. In a placebo-controlled clinical trial, subjects administered a proprietary blend of Clostridium butyricum, Anaerobutyricum hallii, Clostridium beijerinckii, Akkermansia muciniphila, and Bifidobacterium infantis supported healthy glucose levels. (1

This five-strain formulation is available as Glucose Control.

Pendulum ​​supplement plan 

  • Glucose Control: 1 capsule, twice daily with food 
  • Polyphenol Booster: optional add-on to boost Akkermansia, which may further enhance the benefits 


The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

View template in-app
  1. Perraudeau F, McMurdie P, Bullard J, et al. BMJ Open Diabetes Research and Care 2020;8:e001319. doi: 10.1136/bmjdrc-2020-001319